Next, we analyzed phosphorylation and total expression of Syk, SHP2, and Src proteins in 40 specimens of RCC tissues, and quantified that 80% of Syk (32/40) and 72.5% of SHP2 (29/40) were lower, whereas 85% of phospho-Src (34/40) was higher compared to adjacent normal tissue (Fig. 7C). The gene discussed is PTPN11; the disease is renal cell carcinoma.