Previous reports suggested that checkpoint kinase 1 (CHK1) is activated in response to genotoxic damage [33], and phosphorylation of Syk on S295 by CHK1 promotes tumorigenesis in hepatocellular carcinoma via Syk degradation, but these signaling pathways were inconsistent with our results [34]. This evidence concerns the gene CHEK1 and hepatocellular carcinoma.