Noteworthy, Decitabine upregulated Pdl1 expression even other gene expression in gliomas [26, 27], but Tfap2a overexpression could downregulate Decitabine-induced Pdl1 upregulation (Fig. S8C, D), elucidating the AP-2α methylation and AP-2α-suppressed PD-L1 expression in certain types of gliomas. Here, CD274 is linked to central nervous system cancer.