The mean concentrations of 5-HTP, 5-Me-IAA, ILA, Trp, and Xa in the HE group were higher than those in the NC group, while the 3-HAA, 5-HIAA, indole acrylic acid (IA), IAA, IPA, and nicotinic acid levels in the HE group were lower than those in the NC group. The gene discussed is TNFRSF9; the disease is hereditary elliptocytosis.