These down-regulated miRNAs can partially play a role in the pathogenies of GDM through modulating glucose metabolism and Placental trophoblast development via targeting the Insulin-induced gene 1 (Insig1) and Hypoxia Inducible Factor 3 Subunit Alpha (HIF3A) gene by miRNA 29a and 29b respectively [97, 98]. This evidence concerns the gene INSIG1 and gestational diabetes.