Furthermore, transfection of skeletal muscles with miR-92a-3p appears to affect the expression of genes involved in Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathways, as well as those associated with T2D and hyperglycemia pathways, underscoring its ability to regulate glucose metabolism in response to insulin within skeletal muscle cells [68]. Here, INS is linked to type 2 diabetes mellitus.