FOXO1 and cancer: These results verified that the EMT program, cancer stemness, and pre-metastatic microenvironment-related factors might be involved in the formation of IRI-induced disorganized liver microenvironment, which could attract the colonization of HCC cells and eventually contribute to HCC recurrence, while FOXO1 had a function to stabilize the hepatic microenvironment and alleviate the negative effects of IRI.