Compared with the only sparse single tumor nodules in control group, the liver, after adoptively transferring of Th17 cells, presented large and multiple tumor nodules, indicating that Th17 cells have the property of promoting HCC recurrence, and up-regulation of FOXO1 in Th17 cells can partially attenuate the promoting effect (Fig. 9A, B). This evidence concerns the gene FOXO1 and neoplasm.