FOXO1 and hepatocellular carcinoma: These results demonstrated that Th17 cells might have the ability to aggravate HCC recurrence by activating the EMT program, inducing cancer stemness, and promoting the formation of the pre-metastatic microenvironment and angiogenesis in vitro and in vivo, while the characteristics of FOXO1 in negatively regulating Th17 cells to reduce the HCC recurrence was recognized.