Both pCoV-GD01 and SARS-CoV-2 infection readily stimulated the transcription of a large panel of genes related to viral infection or antiviral response, including IFIT1, IFIT2, IFIT3, STAT2, OSA3, IP-10, etc. Gene Ontology (GO) gene set analysis also showed that both pCoV-GD01 and SARS-CoV-2 infection induced a quite similar tendency of overexpression or downregulation of genes (Supplementary Fig. S7b). The gene discussed is IFIT3; the disease is viral infectious disease.