Certain of the laboratory investigations e.g., C-Reactive protein, procalcitonin, other FBC indices (haemoglobin and mean cell volume) and clotting profiles that could have elucidated some of the causes implicated in mortality e.g., severe bacterial infection and coagulopathy, could not be included in the data analysis as they were not available in many cases and when available, were not available within the stipulated T1 and T2 time points. This evidence concerns the gene CRP and blood coagulation disease.