The result showed that 9 of 22 PRGs were significantly difference in two groups, among the expression of BAK1, BAX, CASP5, GZMB, IL1A, IL1B, IRF1 were higher in AD patients than in normal humans, while CHMP2A, CHMP2B were lower in AD patients than in normal humans. This evidence concerns the gene IRF1 and Alzheimer disease.