AVP and calcification: Risk factors for an upgrade to malignancy that can be thought of as favoring OE include [1] a lower amount of biopsy tissue (especially CNB or VAB with >8 G needles), [2] the lack of concordance between pathology results and imaging, [3] no correlation between calcifications in ADH and imaging, [4] residual calcifications after VAB, [5] the imaging size of the lesion (> 15mm), [6] the patient’s age (>50 years), and [7] multifocality of ADH in the biopsy specimens [6, 16–18].