Similarly, the use of SC long-acting insulin was associated with a higher median number of hyperglycaemias per patient (2.5 [1; 4] vs 2 [1; 3]; median difference: 2.5 [95%CI 2; 4]; P < 0.0001) and with higher counts of hyperglycaemia (IRR: 3.58 [2.84; 4.52]; P < 0.0001) (Additional file 1: Table S9). This evidence concerns the gene INS and Hyperglycemia.