Early presymptomatic stages of the disease are diagnosed by the detection of multiple islet autoantibodies, including autoantibodies against insulin (IAA), GAD (GADA), IA-2 (IA-2A) and ZnT8 (ZnT8A) [2], and are defined as stage 1 (normoglycaemia) or stage 2 (dysglycaemia) type 1 diabetes [3–5]. This evidence concerns the gene INS and type 1 diabetes mellitus.