Here, we assess the utility of this approach in explaining the variability in insulin sensitivity as estimated by the M value using high-throughput plasma proteomics in two of the largest studies to date that have implemented the EIC: the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) [14] and the Uppsala Longitudinal Study of Adult Men (ULSAM) [15]. This evidence concerns the gene INS and cardiovascular disorder.