Regarding the role of miR‐125a‐3p in obesity, Yeh et al reported that high levels of miR‐125a‐3p in obese subjects are positively associated with the expression of proinflammatory genes and negatively associated with the insulin receptor and the further downstream target of PI3K, indicating the role of this miRNA in the regulation of the insulin signaling cascade.56 The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.