Recently, they have identified 4 susceptibility loci that are associated with COPD, including 4q22 (FAM13A), 4q31 (HHIP), 15q25 (CHRNA3/CHRNA5/IREB2), and 19q13 (RAB4B, PRDX6, MIA, CYP2A6).8, 9, 10. This evidence concerns the gene PRDX6 and chronic obstructive pulmonary disease.