We identified 30 rare variants likely associated with obesity in 15 candidate genes (LEP, LEPR, POMC, MC3R, MC4R, MRAP2, SH2B1, BDNF, NTRK2, DYRK1B, SIM1, GNAS, ADCY3, RAI1, and BBS2) (Fig. 3A). The gene discussed is ADCY3; the disease is Obesity.