Additionally, we found a novel heterozygous variant in the BDNF receptor gene, NTRK2 gene c.1726C>T p.L576F, in a 4-year-old Qatari boy with obesity, hyperphagia, acanthosis nigricans, and obstructive sleep apnea. Here, NTRK2 is linked to obesity due to melanocortin 4 receptor deficiency.