We detected a novel missense variant of the dual-specificity tyrosine phosphorylation regulated kinase lB gene (DYRK1B), c.1522C>T p.P508S, in a 4-year-old Bangladeshi obese male with BMI of 35 kg/m2 with type 2 diabetes, hypertension, fatty liver with hepatomegaly, and signs of insulin resistance. The gene discussed is DYRK1B; the disease is type 2 diabetes mellitus.