However, based on the genotype–phenotype association, the patient in addition to obesity has type 2 diabetes, hypertension, fatty liver with hepatomegaly, and signs of insulin resistance, which are consistent with the previously described AOMS3 (OMIM:615812), which is caused by variants on DYRK1B. Here, DYRK1B is linked to obesity due to melanocortin 4 receptor deficiency.