Our study revealed that inhibiting YAP expression could hinder tumor growth and macrophages M2‐type polarization, activate Treg cells, activate CD4+ and CD8+ T cells, and regulate the expression of YAP, STAT3, p‐STAT3, PD‐L1, VEGF, and VEGFR‐2. The gene discussed is KDR; the disease is neoplasm.