We found that compared with the sh‐NC group, the sh‐YAP group showed dramatical decreased in tumor weight and volume, number of tumor cells, YAP protein expression, Treg cells, M2/M1 macrophages ratio, IL‐10, TGF‐β, Arg‐1, and CCL‐22 expressions, as well as YAP, STAT3, p‐STAT3, PD‐L1, VEGF VEGFR‐2 expressions. This evidence concerns the gene CD274 and neoplasm.