As a result of adjusting SARS-CoV-2 variants with ACE2 rs1978124 genotypes, only the ACE2 rs1978124 TC genotype in the Omicron BA.5 and Alpha variants was related to the mortality of COVID-19, whereas the TT genotype in the Delta variant was related to COVID-19 mortality (Table 3). This evidence concerns the gene ACE2 and COVID-19.