In conclusion, the finding of this study showed that the ACE2 rs2074192 TT genotype in all three variants, the ACE2 rs2074192 TC genotype in the Alpha and Omicron BA.5 variants and TT genotype in the Delta variant, the ACE2 rs2285666 CC genotype in the Alpha and Delta variants and ACE2 rs2285666 CT genotype in patients infected with the Delta variant was associated with the COVID-19 mortality. This evidence concerns the gene ACE2 and COVID-19.