ACE2 and COVID-19: Based upon an adjustment for gender in ACE2 rs2074192, the COVID-19 mortality rate was associated with TT (P < 0.0001, OR 2.28, 95% CI 1.79–2.09) and CT (P < 0.0001, OR 1.54, 95% CI 1.24–1.92) genotypes in female and TT genotype (P < 0.0001, OR 3.05, 95% CI 2.41–3.85) in male patients (Additional file 1: Table S1).