As shown in Fig. 1, the mortality rate of COVID-19 was significantly higher in patients with ACE2 rs2074192 TT (P < 0.001), ACE2 rs2285666 CC (P < 0.001), and ACE1 rs1799752 DD (P < 0.001) genotypes than in those with the other genotypes, while there was no relationship between ACE2 rs1978124 polymorphism and rate of the COVID-19 mortality (P = 0.090). This evidence concerns the gene ACE and COVID-19.