TNFRSF11B and rheumatoid arthritis: These findings are consistent with Geusens et al.; findings in newly diagnosed RA patients as the first year OPG:RANKL ratio, as measured at baseline, independently predicted 5-year radiographic progression of joint damage as progression of radiographic damage was greatest in patients with a low OPG:RANKL ratio and was lowest in patients with a high OPG:RANKL ratio.