A high RANKL/OPG ratio in patients compared with controls has been reported in children with nephrotic syndrome [3], children with type 1 diabetes milletus,[43] and juvenile SLE [8] whereas Ozkaya et al. found an increased OPG/RANKL ratio in children with CKD representing a compensatory mechanism to the negative balance of bone remodeling in this disease [44]. Here, TNFSF11 is linked to systemic lupus erythematosus.