A high RANKL/OPG ratio in patients compared with controls has been reported in children with nephrotic syndrome [3], children with type 1 diabetes milletus,[43] and juvenile SLE [8] whereas Ozkaya et al. found an increased OPG/RANKL ratio in children with CKD representing a compensatory mechanism to the negative balance of bone remodeling in this disease [44]. This evidence concerns the gene TNFSF11 and type 1 diabetes mellitus.