HFD-fed rats exhibited increased ICP as a function of their bodyweight, as previously demonstrated in a study using young female rats on a shorter duration obesogenic HFD program with similar weight gain, displaying similar increases in ICP, as well as indications of other IIH symptoms including reduced cerebrovascular compliance, papilledema, and headache [53] and aligned with earlier findings in a genetic rat obesity model deficient in the leptin receptor [85], thus manifesting one of the hallmark symptoms of IIH. This evidence concerns the gene LEPR and obesity due to melanocortin 4 receptor deficiency.