At present, NETs or their key components, such as extracellular DNA, nucleosome, MPO, CitH3 and NE, have been shown to play a role in venous thrombosis in a large number of clinical samples and animal experiments, showing their potential as biomarkers to provide evidence for the diagnosis or prognosis of venous thrombosis related diseases. The gene discussed is MPO; the disease is Venous thrombosis.