CXCL12 and neoplasm: as the first assistance of CSCs which can be trained and reprogrammed to obtain a protumorigenic character, in the companionship of other suppressor cells by secreting growth FGF, HGF, and CXCL12, accelerating the tumor As the predominant population in solid tumors, fibroblast cells, named CAF are recruited during the healing process after a sustained inflammation.