Conversely, colocalization supported distinct causal variants for ADRD and PD at the SETD1A/KAT8 (100.0% chance), MAPT (81.6% chance), and GRN (74.2% chance) loci and for ADRD and ALS at the HS3ST5/HDAC2/MARCKS (84.0% chance) and MAPT (63.9% chance) loci. The gene discussed is SETD1A; the disease is amyotrophic lateral sclerosis.