Supporting the relevance of WWOX to AD, WWOX downregulation induced tau hyperphosphorylation in vitro [55], and Wwox knockout mice exhibited large increases in tau aggregation by 3 weeks of age [56] (though Wwox knockout may not be a realistic model for the much gentler perturbation of WWOX expression likely to be effected by a common GWAS variant). Here, MAPT is linked to Alzheimer disease.