Notably, despite extensive pleiotropy at the APOE locus with cardiometabolic and other traits [101], rs429358 (which differentiates APOE4 from APOE3) was not significantly associated with either PD (OR = 1.01, p = 0.46) or ALS (OR = 0.98, p = 0.31). Here, APOE is linked to Parkinson disease.