A recent GWAS for AD and related dementias (ADRD) [22], which pooled AD cases with “proxy cases” having a family history of all-cause dementia, used colocalization analysis to provide evidence that ADRD and FTD with TDP-43 inclusions share causal variants at the TMEM106B and GRN loci. The gene discussed is TMEM106B; the disease is Alzheimer disease.