GRN and Parkinson disease: Both variants are at the GRN locus: rs5848 is located in the 3′ untranslated region (UTR) of GRN, while rs850738 is located approximately 4 kilobases away in an intron of the neighboring gene FAM171A2. Both rs5848 (ADRD OR = 1.07, p = 2.4 × 10−20; PD OR = 1.07, p = 1.8 × 10−12) and rs850738 (ADRD OR = 0.96, p = 3.0 × 10−6; PD OR = 0.93, p = 1.3 × 10−11) had concordant directions of effect on the two disorders.