The second variant associated with both ADRD and PD was the ADRD lead variant rs11787077 (chr8:27,607,795), located in an intron of CLU. Its PD association was weaker than, but concordant with, its ADRD association (ADRD OR = 0.91, p = 1.7 × 10−44; PD OR = 0.96, p = 1.7 × 10−4); colocalization analysis supported a shared causal variant (88.4% chance). Here, CLU is linked to Parkinson disease.