HS3ST5 and Alzheimer disease: Besides HS3ST5 and HDAC2, the only other protein-coding gene within 500 kilobases of rs785129 is MARCKS (myristoylated alanine-rich C-kinase substrate), hyperphosphorylation of which appears to induce Yes-associated protein (YAP)-dependent necrosis of neurons in early-stage AD [80–82].