Of the eleven loci, one was associated with all three disorders (near MAPT/KANSL1), five with ADRD and PD (near LCORL, CLU, SETD1A/KAT8, WWOX, and GRN), three with ADRD and ALS (near GPX3, HS3ST5/HDAC2/MARCKS, and TSPOAP1), and two with PD and ALS (near GAK/TMEM175 and NEK1). This evidence concerns the gene HDAC2 and amyotrophic lateral sclerosis.