The first variant associated with both ADRD and ALS was the ADRD lead variant rs871269 (chr5:151,052,827), located in an intron of TNIP1 and associated with reduced risk of both ADRD (OR = 0.96, p = 8.7 × 10−9) and ALS (OR = 0.95, p = 6.8 × 10−6). The gene discussed is TNIP1; the disease is amyotrophic lateral sclerosis.