TSPOAP1 and amyotrophic lateral sclerosis: The final variant associated with both ADRD and ALS was the ADRD lead variant rs2526377 (chr17:58,332,680), located approximately 4 kilobases upstream from TSPOAP1 and associated with increased risk of both ADRD (OR = 1.05, p = 1.6 × 10−12) and ALS (OR = 1.05, p = 3.4 × 10−5).