The first variant associated with both ADRD and PD was the PD lead variant rs34025766 (chr4:17,967,188 in hg38 coordinates), located in an intron of the transcription factor LCORL. rs34025766 had opposite directions of association with ADRD (odds ratio [OR] = 1.04, p = 2.5 × 10−4) and PD (OR = 0.98, p = 2.9 × 10−10). The gene discussed is LGR5; the disease is Parkinson disease.