TNIP1 and Tay-Sachs disease: Besides TNIP1 and GPX3, the seven other protein-coding genes within 500 kilobases of rs871269 are ANXA6 (annexin A6), the poorly characterized gene CCDC69, the cadherin family member FAT2, the glycolipid transporter GM2A, and the proton-coupled amino acid transporters SLC36A1, SLC36A2, and SLC36A3. Annexin A6 interacts with tau and may affect its subcellular localization within neurons [71], while mutations in GM2A cause an autosomal recessive neurodegenerative syndrome similar to Tay-Sachs disease [72].