NEK1 deficiency also promotes RIPK1-dependent apoptosis and necroptosis of endothelial cells, leading to disrupted blood–brain barrier integrity; supporting the relevance of this mechanism to PD, RIPK1 inhibition reduces neuroinflammation and alpha-synuclein aggregation in the brains of NEK1-deficient mice [99]. The gene discussed is RIPK1; the disease is Parkinson disease.