METTL16 and allergic respiratory disease: Next, the screening range of hub m6A regulators was narrowed down, resulting in three hub genes affecting respiratory allergies: the three "writers" METTL14, METTL16, and RBM15B. METTL14 mainly has a SAM-binding domain and an EPPL motif required for m6A methylation, as well as a coiled-coil domain for mediating protein–protein interactions and a G-rich sequence at the N- and C-terminal ends [44].