In our previous investigation, we found that HMGB3 is overexpressed in HGSOC tissues, and that high HMGB3 levels are associated with shorter overall survival and lymph node metastasis in patients with HGSOC [22], indicating that HMGB3 may have implications in ovarian cancer progression; however, the functions of HMGB3 in ovarian cancer proliferation and metastasis have not been effectively explored. Here, HMGB3 is linked to metastatic malignant neoplasm in the lymph nodes.