EGFR and lung carcinoma: For example, in lung cancers, AXL interacts with epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (ERBB3, also known as HER3) to maintain the activation status of downstream signal pathway, which confers intrinsic resistance to osimertinib in non-small cell lung cancer (NSCLC) cells [9].