CTH and nutritional disorder: For instance, in H.pylori-infected macrophages, cystathionine γ-lyase (CTH, also known as CSE) triggered the mammalian reverse transsulfuration pathway (RTP)-mediated SAM metabolism and induced macrophages activation through enhancing mitochondrial function and glycolysis [11], and H.pylori aggravated the severity of gastric inflammation and the development of premalignant lesions in the setting of iron deficiency through enhanced bile acid production [12, 13].