HMOX1 and hypertensive disorder: In animals, hypertension combined with HHCY caused arterial injury by inhibiting the Nrf2/HO-1 pathway and Nrf2 nuclear transport to increase redox stress [39], inducing inflammation via interleukin-6 (IL-6), nuclear factor-κ-gene-binding (NF-κB) p65/rela and protein kinase B (Akt1) [40–42], and by increasing perivascular collagen and coronary artery wall thickening [43].