Although treatment with a MEK inhibitor is indicated in patients with inoperable, symptomatic NF1-PN, there are data to suggest that treatment of patients with inoperable PN not currently causing clinically significant morbidity but deemed at risk for developing serious PN-related complications may be effective in preventing PN growth and PN-related morbidity [80, 81]. The gene discussed is MAP2K7; the disease is neurofibromatosis type 1.