For example, DRB1*15:01–DRB5*01:01–DQA1*01:02–DQB1*06:02 are overrepresented in patients with multiple sclerosis while HLA-DRB1*03, HLA-DRB1*15, and HLA-DRB1*04 are overrepresented in systemic lupus erythematosus (SLE) and dictate type of auto-antibodies and SLE symptoms [7, 8]. This evidence concerns the gene HLA-DRB1 and systemic lupus erythematosus.