Numerous association studies have correlated SNP rs4420638 with lipid metabolism by revealing strong associations between the minor G-allele and elevated activity of Lp-PLA2 and high serum levels of TC, TG, LDL cholesterol or HDL cholesterol, thus providing evidence for a significant function in dyslipidemia (Kathiresan et al. 2008; Drenos et al. 2009; Suchindran et al. 2010; Liu et al. 2011; Grallert et al. 2012; Breitling et al. 2015; Zhang et al. 2018; Wang et al. 2022). The gene discussed is PLA2G7; the disease is metabolic syndrome.