In the ssGSEA algorithm, CXCL10 had a significant positive correlation with activated CD8 T cell, activated B cell, MDSC, activated CD4 T cell, immature B cell, and type 1 T helper cell and a significant negative correlation with immature dendritic cell, type 17 T helper cell, plasmacytoid dendritic cell, central memory CD4 T cell, and memory B cell in the RA validation set (Fig. 9H). This evidence concerns the gene CD4 and rheumatoid arthritis.