In the CIBERSORT algorithm, CXCL10 had a significant positive correlation with M1 macrophages, gamma-delta T cells, activated memory CD4 T cells, plasma cells, and T follicular helper cells and a significant negative correlation with resting NK cells, resting dendritic cells, and regulatory T cells (Tregs) in the RA validation set (Fig. 9D). Here, CD4 is linked to rheumatoid arthritis.