TMEM37 and viral infectious disease: Interestingly, the expression of PR1 in 35S::sim3|S11/15D-GFP seedlings was increased after TuMV challenge to a level comparable to that of 35S::S11/15D-GFP seedlings (Supplementary Fig. 15c), indicating that sim3|S11/15D is functional and responses to the stimulation of viral infection.