From an indirect comparison with what is observed in aging, as well as after overexpression of the human mutated A53T α-synuclein49, the co-existence of other risk factors, including reduced autophagy/lysosomal degradative capacity, might be critical for determining whether increased expression of α-synuclein-induced mild cognitive impairment will remain stable or will worsen with time. Here, SNCA is linked to Cognitive impairment.