At the same time, pathways analysis showed that TBX15 was involved in ECM-receptor interaction, proteoglycans in cancer, human papillomavirus infection, protein digestion and absorption, AGE-RAGE signaling pathway in diabetic complications, PI3K-Akt signaling pathway, extracellular matrix organization, ECM proteoglycans, collagen biosynthesis and modifying enzymes, MET promotes cell motility and activates PTK2 signaling. This evidence concerns the gene MET and human papilloma virus infection.