At the same time, pathways analysis showed that TBX15 was involved in ECM-receptor interaction, proteoglycans in cancer, human papillomavirus infection, protein digestion and absorption, AGE-RAGE signaling pathway in diabetic complications, PI3K-Akt signaling pathway, extracellular matrix organization, ECM proteoglycans, collagen biosynthesis and modifying enzymes, MET promotes cell motility and activates PTK2 signaling. The gene discussed is RENBP; the disease is cancer.