To identify the immune suppression role of the TGF-β signaling pathway, the cancer genome atlas (TCGA) databases analyze demonstrated that TGFBR1 is significantly upregulated in a broad spectrum of solid tumors including breast invasive carcinoma and pancreatic adenocarcinoma tissues compared to their normal adjacent tissues (Fig. 2a, c, and Supplementary Fig. 1). This evidence concerns the gene TGFB1 and invasive breast carcinoma.