CD274 and neoplasm: In addition, IF staining and flow cytometry results of PD-L1 expression demonstrated that the ELJNV + Laser group could also block the overexpression of PD-L1 caused by IFN-γ in situ by efficiently releasing JQ1, overcoming the inducible immune resistance, and relieving the immunosuppressive tumor microenvironment in pancreatic cancer (Fig. 6p, r, and Supplementary Fig. 48h).