Flow cytometry examination showed that JTP+Laser instead of JP+Laser highly efficiently inhibits IFN-γ-inducible PD-L1 expression on the surface of the tumor cell membrane as free JQ1 in both 4T1 and Panc02 tumor cells in vitro (Supplementary Fig. 43), validating PDT-activatable BRD4 inhibition profile of JTP prodrug. The gene discussed is BRD4; the disease is neoplasm.