The immunohistochemical staining and flow cytometry assay of mouse tumor tissues at the end of the treatment illustrated that ELNV and ELJNV significantly decreased the expression of α-SMA, FAP, and fibronectin, thereby relieving the tumor fibrosis and promoting the tumor-infiltration of CD3+ T cells (Fig. 6i–l, and Supplementary Fig. 47b–d). This evidence concerns the gene ACTA1 and neoplasm.