Both the homotrimeric and biparatopic Bicycles were capable of inhibiting Spike-mediated syncytia formation (Fig. 3e, f and Supplementary Table 7), with similar nanomolar potencies as for cell-free infection (E2 trimer = 0.74 nM and E2E4 = 1.3 nM). This evidence concerns the gene CHMP5 and infection.