Genes involved in endocrine resistance pathways primarily fell into 3 functional categories: ERBB2/IGF1R, CCND1, and BCL2 (Fig. 3c, Supplementary Data 10 and 13), which have been reported to be associated with endocrine resistance15–17 and an increased risk of cancer recurrence in breast cancer18,19. This evidence concerns the gene ERBB2 and cancer.