Next, we analyzed the TOPK and YB1 mRNA levels in different tumors from the Cancer Genome Atlas (TCGA, https://www.genome.gov/Funded-Programs-Projects/Cancer-Genome-Atlas) database and found that the mRNA levels were significantly up-regulated in EC tumor tissues compared with adjacent non-cancerous tissues (Fig. 1e, f). Here, PBK is linked to neoplasm.