Its expression was positively associated with the growth kinetics and motility of tumor cells in breast,[44] ovarian,[45] and prostate cancers.[42] Nevertheless, the mechanism of SEPT9 promoting the expression of hexokinase (HK1, HK2, HKDC1) and pyruvate dehydrogenase kinase (PDK1) remained obscure. Here, PDK1 is linked to Familial prostate cancer.