Seven genes linked to sexual/physical abuse (TAF1), family instability (PKD2), financial hardship (FBXL16, XKR6), or one-adult households (DSP, CUX2, STK38L) showed evidence of strong functional constraint through analyses of probability of intolerance to loss-of-function mutations(34)(Table S5; Figure S9). This evidence concerns the gene TAF1 and sexuality.