Inferred CNV from our high resolution single nucleus analysis identifies Chr8p loss (containing NKX3–1, BMP1, FGFR1 genes and multiple microRNAs) as one of the earliest genetic events in prostate tumorigenesis, shared by >43% of cancer cells in GS6 tumors (Figure S4A). The gene discussed is NKX3-1; the disease is male reproductive organ cancer.