Across all 33 cancer types, CD1A-IFI16 demonstrates the greatest degree of DNA hypomethylation compared with all other core PMDs (Figure 4E), and 19 of the 33 cancers show a significant correlation between hypomethylation of this locus and reduced RNA expression of CD1A-IFI16 resident genes (Figure S5H). This evidence concerns the gene IFI16 and cancer.