TNFRSF1A and skin infection: To determine the relative contribution of TNFR1 and TNFR2 to host defense against S. aureus skin infections, we performed our intradermal S. aureus skin infection model in WT, TNFR1-deficient (TNFR1−/−), and TNFR2-deficient (TNFR2−/−) mice.