TNFRSF1B and Autoimmunity: For example, TNFR2 drives Treg differentiation, expansion, and anti-inflammatory responses in models of autoimmunity (8, 18, 66) and activates myeloid-derived suppressor cell (MDSC) (67) and natural killer (NK) cell (68) suppressor functions in the tumor microenvironment, suggesting that TNFR2 signaling has cell-specific and contextual-dependent immunological functions.