CLCNKB and Gerstmann syndrome: In the Chinese population, the most common mutations were p.T60M and p.D486N, whereas the most common mutations in the European population were p.A313V, c.1180 + 1G > T, p.G741R, p.L859p, p.R861c, c.2883 + 1G > T, and p.C994Y.[12] In addition, some GS patients are caused by CLCNKB gene mutations,[13] but the specific mechanism is still unclear.