Hypokalemia prevents the closure of ATP-sensitive potassium channels on pancreatic islet β cells, causing reduced insulin secretion and, in turn, causing disturbed glucose metabolism with further progression to T2DM.[2] Magnesium is a key cofactor for several enzymatic reactions in glucose metabolism, involved in regulating the activity of all enzymes in phosphorylation. The gene discussed is INS; the disease is type 2 diabetes mellitus.