1. History of allergic rhinitis and asthma no tumor, no oral/intravenous hormones and immunosuppressants were used.2. Repeated cough, expectoration and dyspnea for more than 10 yr.3. Serum total IgE level increased. The number of neutrophils in blood is normal. Serum GM (−) and serum aspergillus fumigatus specific IgE (−)4. Chest CT: atelectasis of middle lobe of right lung, ground glass shadow, tree-bud sign.5. Etiology: bronchoalveolar lavage fluid and sputum culture: aspergillus fumigatus (+)6. Voriconazole combined with amphotericin has poor symptom control and imaging improvement. This evidence concerns the gene IGHE and asthma.