Furthermore, UGT1A10 was indicated to facilitate detoxification of CPT-11/SN38 in colorectal cancer and lung cancer (Oguri et al., 2004; Cummings et al., 2006; Raynal et al., 2010); however, its role in pancreatic cancer remains unknown. The gene discussed is UGT1A10; the disease is familial pancreatic carcinoma.