NR4A1 and serous adenocarcinoma: This age interaction may support a study reporting shorter survival in younger patients with low-grade serous carcinomas.34 That study team speculated the possible effects of estrogen/progesterone receptor activity in younger patients and hypothesized that younger patients undergoing NACT for 3 to 4 months have their ovaries in situ, and hormone receptor–expressing tumors may continue to grow until oophorectomy at interval cytoreduction.34