SLC1A5 and colorectal cancer: Li et al. found that arsenic trioxide (ATO) can increase the expression of transcription factor GCM1, which in turn increases the expression of syncytin-1 and its receptor SLC1A5, mediating cell fusion, inducing the formation of the polyploid giant cancer cells (PGCCs) in colorectal cancer, promoting the migration, proliferation and invasion of colorectal cancer cells.