And syncytin-1 could also activate the phosphorylated cyclic-AMP response binding protein (CREB) site on the small conductance Ca2+ -activated K+ channel protein 3 (SK3) promoter, causing downstream gene SK3 transcription, and inducing calcium influx via a voltage-independent pathway, finally causing proliferation and migration of NB cells [98]. This evidence concerns the gene KCNN3 and neuroblastoma.