Lue and colleagues showed the neuroprotective role of REST in AD by suppressing oxidative stress-mitigating genes and apoptosis-inducing genes that promote amyloid-protein toxicity, while its role in the stimulation of brain oxidative-resistant genes, such as forkhead box protein O1 (FOXO1), indicates that REST could also be a transcriptional activator in the pathogenesis of AD [10]. Here, REST is linked to Alzheimer disease.