In cardiomyocytes, it is suggested that STIM1 contributes to the development of cardiac hypertrophy and advancement of heart disease, although how STIM1 expression and functionality impact S/ER Zn2+ and Zn2+ transporters has not yet been investigated (Bootman and Rietdorf, 2017). This evidence concerns the gene STIM1 and cardiac hypertrophy.