The protective effects of matrine on interleukin-10 (IL-10)-deficient colitis mice have been demonstrated,8 while other studies found its effects on mice colitis induced by 2,4,6-trinitrobenzene sulfonic acid.9,10 Another study investigated the model of dextran sulfate sodium (DSS)-induced colitis and found that matrine protects against murine colitis by improving gut barrier integrity through the peroxisome proliferator-activated receptor-α (PPAR-α)-signaling pathway as well as the regulation of gut microbiota.6 Here, PPARA is linked to colitis.