PPARA and ulcerative colitis: One study showed that matrine significantly lowers the histological score of ulcerative colitis (UC) mice, by decreasing the inflammatory cytokines and maintaining the intestinal barrier function and integrity.6 Further study showed that matrine significantly inhibited the PPAR-α-signaling pathway.6 Furthermore, matrine could regulate the intestinal microbiota, by regulating Barnesiella intestinihominis and Helicobacter ganmani.