Furthermore, they showed that miR155 may regulate intestinal microbiota via the toll-like receptors-4/myeloid differentiation factor 88 (TLR4/MYD88) pathway, leading to serious acute pancreatitis (SAP)-related intestinal injury by the regulation of inflammatory mediators.23 Another study showed the association between miR-155 and intestinal barrier dysfunction by nuclear factor (NF)-kappaB.15 Mice were injected with an miR-155 inhibitor, which recovered from the intestinal injury. The gene discussed is TLR4; the disease is acute pancreatitis.